SS-31

SS-31  | ≥99% HPLC Verified

SS-31 (elamipretide) is a synthetic tetrapeptide investigated in laboratory research for its interactions with mitochondrial membranes and cardiolipin-associated signaling pathways. This peptide has been widely examined in studies evaluating mitochondrial bioenergetics, membrane stability, and oxidative stress mechanisms. Synagenics SS-31 is produced to research-grade standards with batch-specific HPLC verification confirming ≥98% purity.

Molecular Mechanism of Action

SS-31 functions through selective interaction with cardiolipin, a phospholipid located almost exclusively within mitochondrial inner membranes. Research published in Biochimica et Biophysica Acta demonstrates cardiolipin stabilization and mitochondrial membrane interaction associated with SS-31 in experimental models — PMID: 24374109.

Additional investigations report SS-31 involvement in mitochondrial respiratory chain regulation and cytochrome c oxidase activity modulation. Studies indicate SS-31 interaction with mitochondrial respiratory complexes in laboratory models — PMID: 28835392. Further research examining mitochondrial membrane potential and peptide localization has been documented in mitochondrial membrane studies involving SS-31 — PMID: 22406319.

Researchers seeking broader indexed literature may review SS-31 mitochondrial peptide research on Google Scholar for studies examining mitochondrial energetics, membrane stability, and cardiolipin interactions.

Research Applications

SS-31 is commonly examined in laboratory environments studying mitochondrial membrane dynamics, cellular energetics, and oxidative stress pathways. The peptide’s affinity for cardiolipin-containing membranes allows researchers to investigate mitochondrial structural stability and electron transport chain interactions in controlled experimental systems.

Laboratory investigations may include:

• Mitochondrial membrane stabilization studies
• Cardiolipin interaction assays
• Cellular energetics analysis
• Oxidative stress response observation
• Mitochondrial respiratory chain evaluation

All experimental investigations remain limited to controlled laboratory research environments.

Research Parameters

Laboratory preparation commonly involves reconstitution using bacteriostatic water to create stable peptide solutions suitable for experimental use. Researchers may calculate preparation volumes and concentration estimates using the Synagenics peptide reconstitution calculator.

Lyophilized SS-31 is typically stored under frozen laboratory conditions to maintain peptide stability. Following reconstitution, research environments generally maintain peptide solutions under refrigerated conditions while avoiding repeated freeze-thaw cycles.

Molecular Weight: 639.8 g/mol
Sequence: H-D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH2
Form: Lyophilized peptide powder
Purity: ≥99% by HPLC verification

Synagenics Quality Verification

Why Researchers Choose Synagenics SS-31

Synagenics SS-31 research peptide undergoes independent third-party analytical testing to verify peptide identity and purity standards. Each batch includes a certificate of analysis documenting chromatographic purity and molecular confirmation through mass spectrometry.

Why Researchers Choose Synagenics:
→ Batch-specific COAs — not generic lab reports
→ Independent analytical verification
→ ≥99% HPLC purity standards
→ Ships within 24 hours
→ Research support resources available

Researchers investigating mitochondrial signaling pathways may also evaluate complementary compounds including MOTS-C, NAD+500, and Glutathione 1500mg when designing broader mitochondrial research models.

Frequently Asked Questions

What is SS-31?

SS-31 (elamipretide) is a synthetic tetrapeptide investigated in laboratory research involving mitochondrial membrane stability, cardiolipin interactions, and cellular energetics.

What purity standard does Synagenics SS-31 meet?

Synagenics SS-31 is independently verified through third-party HPLC analysis confirming ≥98% purity, with batch-specific certificates of analysis provided for research documentation.

How should SS-31 be stored for research use?

Lyophilized SS-31 is generally maintained under frozen laboratory storage conditions. Following reconstitution, controlled refrigerated storage is commonly used for short-term experimental stability.

How is SS-31 prepared for laboratory research?

Laboratory preparation typically involves reconstitution with sterile bacteriostatic water under controlled handling conditions. Researchers may use the Synagenics reconstitution calculator to estimate preparation volumes and concentrations.

What research areas commonly examine SS-31?

SS-31 is often investigated in laboratory studies examining mitochondrial energetics, cardiolipin interactions, membrane stability, and oxidative stress signaling pathways.

Does Synagenics provide documentation with SS-31 orders?

Yes. Each order includes batch-specific analytical documentation including HPLC purity verification and mass spectrometry confirmation.

Research Use Only Disclaimer: For research purposes only. Not for human consumption. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.