On March 6, 2026, PeptideSciences.com went dark without public explanation. For a significant portion of the research compound community, it had been one of the most relied-upon sources for documented, third-party-tested synthetic compounds over the course of several years. Its voluntary closure created an immediate sourcing gap — and a clear, urgent question for investigators with active research protocols: where do researchers go now?
This page exists to answer that question directly and completely. Synagenics carries a broad catalog of ≥99% HPLC-verified research compounds, each backed by independent third-party analytical testing through Freedom Diagnostics and full certificate of analysis documentation accessible before purchase. The documentation standard researchers depended on at Peptide Sciences is the same standard Synagenics is built on — batch-specific, independently verified, and available on request for every compound in the catalog.
Peptide Sciences was not a casual vendor. It maintained one of the more rigorous documentation standards in the research compound space — HPLC chromatograms, mass spectrometry confirmation, and research-grade sourcing. When a supplier of that caliber exits the market, researchers cannot simply migrate to the next available name in search results. The documentation criteria that made Peptide Sciences trustworthy are the same criteria that need to be applied to any alternative. This page addresses that process directly.
All compounds listed on this page are supplied strictly for in vitro and laboratory research use only. Not for human consumption. Not for use in clinical or diagnostic procedures.
Why Peptide Sciences Closing Matters to the Research Community
PeptideSciences.com had accumulated years of trust among researchers across multiple disciplines — cellular biology, metabolic research, neuropeptide investigation, dermal biology, and longevity science. It was not just a vendor. It was a reference point. Researchers knew what they were getting because the documentation consistently backed it up. Batch-specific HPLC data, mass spectrometry confirmation, independent laboratory testing, and a research-use-only supply chain were the foundation of that trust.
The compound research market entered 2026 in a state of significant consolidation. Regulatory attention, payment processing pressure, and voluntary business decisions by major operators reduced the number of active, documented suppliers — while demand from researchers, laboratory investigators, and scientific institutions continued to grow. The closure of Peptide Sciences accelerated that consolidation dramatically. Over one million monthly visitors to PeptideSciences.com are now searching for documented alternatives. That search demand is real, urgent, and concentrated on a smaller pool of remaining suppliers.
The risk in that environment is not just sourcing difficulty. It is sourcing quality. When a trusted supplier exits, lower-quality vendors move into the vacuum. Researchers who do not apply rigorous documentation criteria when evaluating alternatives risk compromising the integrity of their work. Purity data, molecular identity verification, and independent testing are not optional extras — they are the baseline that separates research-grade suppliers from unverified ones.
The Documentation Standard Researchers Should Require
Before evaluating any Peptide Sciences alternative, researchers should establish the non-negotiable documentation criteria that any supplier must meet. These are the same criteria Peptide Sciences met consistently and the same criteria Synagenics applies to every compound in its catalog.
≥99% HPLC Purity — Per Batch
High-performance liquid chromatography is the analytical standard for confirming compound purity. The accepted research-grade threshold is ≥99% purity as a percentage of peak area. This data must be batch-specific — not generic, not lot-pooled, and not extrapolated from a previous batch. Any supplier who cannot provide HPLC data at or above 99% for the specific batch being purchased does not meet research-grade standards.
Mass Spectrometry Molecular Identity Confirmation
HPLC confirms purity but cannot confirm that the compound is what it is claimed to be. Mass spectrometry verifies molecular identity by matching the observed molecular weight against the theoretical molecular weight of the intended compound sequence. Both data points together — HPLC purity and MS identity confirmation — constitute the minimum analytical standard for research-grade compound sourcing. Either alone is insufficient.
Independent Third-Party Laboratory Testing
In-house testing by the supplier itself creates an obvious conflict of interest. The testing laboratory must be independent of the supplier — an accredited external analytical facility with no commercial relationship to the outcome of the test. Peptide Sciences used independent testing. Synagenics uses Freedom Diagnostics, an independent accredited analytical laboratory, for all third-party testing across the full catalog.
Batch-Specific Certificates of Analysis
A certificate of analysis is only as useful as its specificity. Generic COAs — documents that cover entire product lines rather than individual batches — do not provide meaningful quality assurance for research use. Batch-specific COAs identify the exact batch being purchased, report analytical data for that specific production run, and carry a testing date that allows researchers to assess the currency of the data. Any supplier who cannot produce batch-specific COA documentation before purchase should not be considered a research-grade alternative.
Research-Use-Only Supply Chain
Research compounds must be sold and marketed exclusively for in vitro and laboratory research use. Any supplier making therapeutic claims, outcome-based statements, or human use implications about compounds in their catalog is operating outside research-grade standards — and creating legal and scientific credibility risks for researchers who purchase from them. Synagenics maintains research-use-only framing across the entire catalog with no exceptions.
Compounds Available at Synagenics — The Peptide Sciences Catalog Covered
The following compounds from the Peptide Sciences catalog are available at Synagenics with equivalent or superior documentation standards. All meet the ≥99% HPLC purity threshold with mass spectrometry confirmation and batch-specific COA documentation from Freedom Diagnostics.
Cellular and Tissue Repair Research
BPC-157 was one of the highest-volume compounds at Peptide Sciences, studied extensively in published literature for its influence on nitric oxide pathway modulation, VEGFR2-associated angiogenic signaling, and gene expression patterns including Egr, Nos, Vegf, and Srf. It is available at Synagenics in multiple vial sizes with full analytical documentation. Researchers combining BPC-157 with TB-500 in combination protocols can source the BPC-157 + TB-500 Blend directly — a combination that was among the highest-volume purchase patterns at Peptide Sciences prior to its closure.
GHK-Cu, a copper-complexed tripeptide studied for its influence on metalloproteinase activity, extracellular matrix regulation, and redox signaling in dermal and cellular research models, is available with full COA documentation. SS-31, a mitochondria-targeting tetrapeptide examined for its influence on oxidative phosphorylation efficiency and mitochondrial membrane integrity in cellular aging models, is also available.
Metabolic and Longevity Research
NAD+ — nicotinamide adenine dinucleotide — is available for researchers investigating cellular energy metabolism, sirtuin activation, and DNA repair pathway biology. MOTS-c, a mitochondrial-derived peptide investigated for its influence on AMPK signaling, glucose metabolism, and cellular stress response, is available with full documentation. 5-Amino-1MQ, a small molecule inhibitor of NNMT studied in the context of adipogenesis and metabolic rate regulation, and IGF-1 LR3, a long-acting analog of Insulin-like Growth Factor 1 used in cellular proliferation and growth factor pathway research, are both available.
Growth Hormone Axis Research
Sermorelin, a 29-amino acid fragment of endogenous GHRH studied for its influence on pituitary growth hormone secretion dynamics, is available. Tesamorelin, a stabilized GHRH analog with an extended pharmacological profile examined in research contexts related to visceral adipose tissue biology and growth hormone axis modulation, is also in the catalog with full analytical documentation.
Neuropeptide Research
Semax, a heptapeptide analog of ACTH(4-7) studied for its influence on BDNF expression, dopaminergic signaling, and neuroprotective pathway research in experimental models, is available. Epitalon, a synthetic tetrapeptide studied for its influence on telomerase activity, pineal gland function, and cellular senescence markers in longevity-focused research, is available with full COA documentation from Freedom Diagnostics.
Dermal and Cosmetic Research
Snap-8, an octapeptide studied for its influence on SNARE complex formation and neuromuscular junction dynamics in dermal research models, is available. Melanotan II, a cyclic heptapeptide analog of alpha-MSH studied for its influence on melanocortin receptor signaling and pigmentation biology, is available with full analytical documentation.
The BPC-157 and TB-500 Combination — Peptide Sciences’ Highest Volume Search Term
Among all compound searches associated with Peptide Sciences, the BPC-157 and TB-500 combination was consistently among the highest-volume purchase and search patterns. Researchers investigating the complementary actin pathway mechanisms of these two compounds — BPC-157 operating upstream at the gene expression level, TB-500 operating downstream through actin sequestration — drove sustained demand for both compounds sourced together.
Published research has examined the BPC-157 and TB-500 combination across fibroblast migration, angiogenic signaling, tissue remodeling quality, and inflammatory phase transition endpoints. The mechanistic rationale centers on the two compounds’ distinct but potentially additive engagement of the actin pathway — BPC-157 increasing transcriptional actin production, TB-500 directing that actin pool toward cytoskeletal reorganization and cellular movement.
Synagenics carries the BPC-157 + TB-500 Blend for researchers sourcing both compounds together for combination protocols. Full analytical documentation — HPLC purity data, mass spectrometry confirmation, and batch-specific COA from Freedom Diagnostics — is available for the blend product.
Key published references for BPC-157 and TB-500 research:
- Sikiric P et al., “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157,” Current Pharmaceutical Design, 2018. View on PubMed →
- Hsieh M-J et al., “Modulatory effects of BPC 157 on vasomotor tone and the Src-Caveolin-1-eNOS pathway,” Scientific Reports, 2020; 10(1): 17078. View on PubMed →
- Goldstein AL, “History of the Discovery of the Thymosins,” Annals of the New York Academy of Sciences, 2007; 1112: 1–13. View on PubMed →
- Malinda KM et al., “Thymosin Beta-4 Stimulates Directional Migration of Human Umbilical Vein Endothelial Cells,” FASEB Journal, 1997; 11(6): 474–481. View on PubMed →
Why Researchers Are Moving to Synagenics
The compound research community does not move to a new supplier lightly. Years of trust built through consistent documentation, reliable purity data, and professional research-use-only framing are not easily replicated. Synagenics was built on the same documentation philosophy that made Peptide Sciences the reference point it was — because that philosophy is not a differentiator in this space. It is the minimum standard.
What Synagenics offers researchers displaced by the Peptide Sciences closure:
Third-Party Testing Through Freedom Diagnostics
Every compound in the Synagenics catalog is tested by an independent accredited analytical laboratory. Testing is not performed in-house. Results are not self-reported. HPLC purity data and mass spectrometry confirmation are generated by an external facility with no commercial interest in the outcome — which is the only testing model that provides meaningful quality assurance for research use.
Batch-Specific COA Documentation
Certificates of analysis at Synagenics are batch-specific. Each COA identifies the specific production batch, reports HPLC purity as a percentage of peak area, includes mass spectrometry molecular identity confirmation, identifies a third party laboratory as the testing laboratory, and carries a testing date. Generic or lot-pooled documentation is not used. Researchers can request COA documentation before completing any purchase.
Research-Use-Only Framing — No Exceptions
Synagenics maintains research-use-only positioning across the entire catalog. No compound is marketed with therapeutic claims, outcome-based language, or human use implications. All product pages, research articles, and catalog descriptions maintain strict compliance with research compound sourcing standards. This protects the scientific integrity of researcher procurement and maintains the credibility of the supply chain.
Domestic Shipping From Port St. Lucie, Florida
All orders ship from Port St. Lucie, Florida. Domestic shipping timelines are confirmed at checkout. Canada shipping is available. Bitcoin and credit card are accepted at checkout — providing payment flexibility for researchers and institutions with different procurement requirements.
Frequently Asked Questions: Sourcing After Peptide Sciences
Why did Peptide Sciences close?
PeptideSciences.com went dark on March 6, 2026 without public explanation. No forwarding address, no statement, and no transition guidance was provided. The voluntary nature of the closure suggests an internal business decision rather than a regulatory enforcement action, but no official explanation has been published as of the date of this page.
Is Synagenics a direct Peptide Sciences replacement?
Synagenics is an independent research compound supplier that meets the same documentation standards Peptide Sciences maintained — ≥99% HPLC purity, mass spectrometry confirmation, and independent third-party COA documentation. It is not affiliated with Peptide Sciences in any way. Researchers evaluating Synagenics should apply the same documentation criteria they applied to Peptide Sciences and confirm that those criteria are met before purchasing.
Does Synagenics carry all the same compounds Peptide Sciences offered?
Synagenics carries a broad catalog covering the majority of compounds that drove research demand at Peptide Sciences — including BPC-157, the BPC-157 + TB-500 Blend, GHK-Cu, Epitalon, Semax, Sermorelin, Tesamorelin, NAD+, MOTS-c, IGF-1 LR3, Snap-8, Melanotan II, SS-31, and 5-Amino-1MQ. The full catalog is accessible at the Synagenics shop. Catalog expansion is ongoing.
How do I access certificates of analysis at Synagenics?
Certificates of analysis from Freedom Diagnostics are available on individual product pages and upon direct request before purchase. All COAs are batch-specific — identifying the exact production batch, reporting HPLC purity data, and including mass spectrometry confirmation. Researchers can request documentation for any compound in the catalog prior to completing a purchase.
Does Synagenics ship to Canada?
Yes. Canada shipping is available. Domestic U.S. shipping timelines and Canada shipping options are confirmed at checkout.
What payment methods does Synagenics accept?
Synagenics accepts credit card and Bitcoin at checkout. Bitcoin payments are processed through a secure gateway. Both payment options are available at the time of purchase with no minimum order requirement.
Browse the Synagenics Research Compound Catalog
The complete Synagenics research compound catalog — including all compounds referenced on this page and additional compounds not listed here — is available through the shop. All listings include ≥99% HPLC purity data, mass spectrometry confirmation, and batch-specific certificate of analysis documentation.Researchers displaced by the Peptide Sciences closure will find the documentation standard they relied on maintained consistently across the Synagenics catalog.
All products are supplied strictly for in vitro and laboratory research use only. Not for human consumption. Not for use in clinical or diagnostic procedures. These statements have not been evaluated by the Food and Drug Administration.
Fast Shipping Nationwide
Synagenics ships to all 50 US states. Florida and Southeast researchers typically receive orders within 1–2 business days. All other states 2–4 business days. Same-day dispatch, flat-rate $9.99.